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KMID : 1059519990430060676
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Journal of the Korean Chemical Society
1999 Volume.43 No. 6 p.676 ~ p.681
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A Highly Efficient Synthesis of Itraconazole Intermediates and Their Analogues
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Ahn Chong-Il
Myoung Young-Chan
Choi Ha-Young
Kim Seung-Jin
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Abstract
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Itraconazole is an important drug for oral treatment of histoplasmosis and blastomycosis. ltraconazole has been the targets of many synthetic efforts due to their diverse antifungal activities. ln this study, an efficient synthetic route for Itraconazole intermediates has been developed using new procedures. Also, ltraconazole analogues introducing 2- and 3-methoxy group instead of ltraconazole intermediates with 4-methoxy group were synthesized.
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